The tenth e-Science All Hands Meeting (AHM) will be held from 26th-29th September 2011, in the historic city of York, United Kingdom. The main themes will be shared infrastructures, using the cloud in research, end-user engagement, applications (e-science, e-social science, research in the arts and humanities). The conference will feature keynote presentations, workshop sessions, poster presentations and demonstrations. A series of tutorials for delegates will be held on Monday 26th September 2011, the first day of the conference. Papers will be peer reviewed and published in a special issue journal (to be confirmed). There will be a small exhibition area and opportunities for networking. The conference is expected to attract over 200 international delegates from industry and the academic community.